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the Grafex at night because I take a low dose of blood pressure and Thyroid medicine, and he did not want it to interfere, though he wasn’t sure if it would or not. Something else happened to me after starting the Grafex. Seem as if I took it at night, I did not wake up as much as I normally do, and I have more energy in the morning. I turn 83 next monthand I am grateful for any day when I feel good!